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Preclinical studies of various integrin antagonists have shown that they are effective in blocking tumor progression

Important safety considerations include contraindications in patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, caution in those with a history of pancreatitis, increased risk of gallbladder disease, potential for acute kidney injury with dehydration, and possible worsening of diabetic retinopathy with rapid glycemic improvement

Lotz et al., 2021)

Chronic injury management Chronic injuries that haven't responded to conventional treatment represent another common use case